Error 500 for ACP and threads


I have a problem that I really hope someone can help with. I can see the main page, but if I try to enter a thread I receive an Error 500. Most worrying, I can get access to the ACP. I receive the same error. Does anyone have any ideas? Thanks in advance.
Thanks for the help, but it didn't seem to work. I managed to recover everything from my daily back-up, though, and it all seems to be working now. I'll have to see if I can find the problem though, in case it happens again.
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