Best day and time to send email newsletters?

[jauburn]

For those of you who have experimented with various days and times to send email newsletters, what have you found works the best?

I know the answer to this can be partially or wholly dependent upon your particular audience, but still I think it would be interesting to hear the experience of admins on this topic.

 

[jellytoe]

Totally depends on audience. I have found that for me middle of the day Wednesday. My thinking is that work and play are minimal at this time so users have free time to read my site and hopefully participate.