Yup, Suhosin is mostly dead nowadays, and the Suhosin-NG people have been contributing to Snuffleupagus, where most of this effort happens these days.
We do use the latter for both our main website and XenForo 2 without issues, and we contributed back a (working-for-us-with-our-set-of-add-ons) basic XF-specific config of it
here.
But your mileage may vary, and you'll want to dig into your server logs to use it comfortably. There will be false-positives from time to time as well.
As for whether it's worth it, that depends on how paranoiac you are about security. We are, so we use it alongside modsecurity, but many people will say that it's fine not to, and they're not necessarily dumb/wrong.