Not always tedious. I usually (when having problems) uncheck 3 at a time and then refresh to see if I'm still having that problem. If the problem stops then I know it's one of those 3. Just basically opposite of what is done by turning all off and then turning them on 1 at a time.
The benefit I see to this is it would make it easy to quickly see if it's an add-on or not, but I do that by just disabling add-ons in the config.php - it disables all functions/features of the add-on so you can be assured there are no "left-overs" to interfere.