Once we release a new release like XenForo 2.2, we stop supporting the previous release.
As of yesterday, XenForo 2.1 is no longer supported so you should move to maintaining only a 2.2 version of the language and people should upgrade to 2.2.
We can't necessarily guarantee backwards compatibility but I don't foresee particular issues with using a 2.2 supported language on XF 2.1.
Significantly, if we reuse an existing phrase for an existing function but the functionality changes then the phrase may not make sense in XF 2.1.