This will require the following:
1) Only the a-z A-Z and 0-9 are allowed.
2) Username cannot be all numbers.
3) Username cannot be all caps.
Code:
^[a-zA-Z0-9]*[a-zA-Z][a-zA-Z0-9]*[a-z][a-zA-Z0-9]*$
Add to the following field:
Admin Control Panel -> Options -> User Registration -> User Name Match Regular Expression: