Well I already have jailed/chroot Nginx vhost menu working for Centmin Mod - just undergoing more internal tests while I build out other Centmin Mod feature support i.e. including Apache 2.4 event + PHP-FPM and OpenLiteSpeed + LSAPI PHP integration and concurrent mulitple PHP version support per Nginx vhost domain - already testing concurrent PHP 5.5, 5.6 or PHP NG (php-fpm) automated menu install and upgrade support. domain1.com using PHP 5.5 while domain2.com uses PHP 5.6I will never go this route, is a bit extreme. You are embarking on a HUGE work load.
If your system is well configured, you will not have any issues. For example, AXIVO PHP rpm is designed to recursively execute code present ONLY on /var/www directory, anywhere else it will not.