We have over forty usergroups, all which we consider vital and over twenty-five thousand members. On larger forums we're noticing a ton of time outs, primarily, Server Did Not Respond In Time. We tried the fixes here. But, they do seem to save but, we still get the error spat out. Our statistics: 26,760 members. Total of 41 usergroups. 443 nodes. We consider most vital, and, we haven't had this problem of a slow admin panel on our old software. We're pleased that posting/thread making is fast/normal and responses are. It's just it's quite slow creating new nodes, using an addon permission like LiquidPro's Simpleforms that has to update all usergroup permissions, or saving new permissions for a usergroup that's large.