its as easy as setting a config file up to point to your buckets with the correct credentials.
if you can figure out how to connect to a mysql db (user,name,host, port, etc) than you can do this too.
there's a config to turn it on (over default local storage)
a config to store to the bucket
a config to read from the bucket
Assuming you have the credentials/acl's/policys/securty already set up on s3 anyway