I've been able to reproduce this on a custom ACP page with color pickers, but not the style properties page. Not sure what is different there.
When having multiple color pickers A and B on a page, cycling back to color picker A after sequentially opening and setting a value for both will break color picker A. This is reproducible with any number of color pickers, with any color picker that is opened for the first time breaking all others that have been opened before.
View attachment AgileUnsightlyCrustacean.webm