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When I come back to the site, I go to alerts, to see what content is relative to me.

Then I go through news-feed in a second browser, to keep track of the content currently relative to me and my friends.

And in the mean time I browse What's new to see all content available on the site. Without the follow/likes/quotes listings. just pure threads.

I use what's new the most, frequently update the news feed, and use alert only every so often, to see if there are new likes or follows, etc.